Conjugation of primary amino and hydroxylamino groups with acetate, catalyzed by acetyl
CoA-dependent arylamine acetyltransferase (NAT) enzymes, may play an important role in
the intricate series of metabolic pathways that produce or prevent toxicity following exposure
to homo-and heterocyclic arylamine and hydrazine xenobiotics. Two independently
regulated and kinetically distinct human acetyltransferases are now known to exist, namely
NAT1 and NAT2. Interindividual variation in NAT2 function is associated with the classical …