Systemic inflammation, cellular influx and up-regulation of ovarian VCAM-1 expression in a mouse model of polycystic ovary syndrome (PCOS)

ME Solano, VA Sander, H Ho, AB Motta… - Journal of Reproductive …, 2011 - Elsevier
PCOS, a major cause of anovulatory sterility, is associated with obesity, insulin resistance
and chronic inflammation. New evidence suggests that the immune system aggravates the
clinical features of PCOS. Our aim was to study the immune, metabolic and endocrine
features of a mouse model of PCOS elicited by androgenisation using
dehydroepiandrosterone (DHEA). We observed a significant weight gain and insulin
resistance in DHEA-androgenised mice, coupled with the formation of ovarian follicular …