PKMζ, LTP maintenance, and the dynamic molecular biology of memory storage

TC Sacktor - Progress in brain research, 2008 - Elsevier
How memories persist is a fundamental neurobiological question. The most commonly
studied physiological model of memory is long-term potentiation (LTP). The molecular
mechanisms of LTP can be divided into two phases: induction, triggering the potentiation;
and maintenance, sustaining the potentiation over time. Although many molecules
participate in induction, very few have been implicated in the mechanism of maintenance.
Understanding maintenance, however, is critical for testing the hypothesis that LTP sustains …