Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
K Plant, KA Pelkey, ZA Bortolotto, D Morita… - Nature …, 2006 - nature.com
K Plant, KA Pelkey, ZA Bortolotto, D Morita, A Terashima, CJ McBain, GL Collingridge…
Nature neuroscience, 2006•nature.comPostnatal glutamatergic principal neuron synapses are typically presumed to express only
calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here,
however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal
neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-
AMPARs are present transiently, being replaced by GluR2-containing AMPARs∼ 25 min
after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell …
calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here,
however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal
neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-
AMPARs are present transiently, being replaced by GluR2-containing AMPARs∼ 25 min
after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell …
Abstract
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs ∼25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
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