Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats
M Krug, B Lössner, T Ott - Brain research bulletin, 1984 - Elsevier
Freely moving rats, chronically implanted with stimulation electrodes in the medial entorhinal
cortex and recording electrodes in the dentate gyrus, received two 400 μg intraventricular
injections of anisomycin during a tetanization procedure that induced a long-lasting
potentiation (72 hours) of the monosynaptic field potential. Inhibition of protein synthesis
during the tetanization procedure did not immediately influence the induction of long-term
potentiation (LTP). However, 3–4 hours after the beginning of tetanization the potentiation …
cortex and recording electrodes in the dentate gyrus, received two 400 μg intraventricular
injections of anisomycin during a tetanization procedure that induced a long-lasting
potentiation (72 hours) of the monosynaptic field potential. Inhibition of protein synthesis
during the tetanization procedure did not immediately influence the induction of long-term
potentiation (LTP). However, 3–4 hours after the beginning of tetanization the potentiation …