LATS (large tumor suppressor) or warts is a Ser/Thr kinase that belongs to the Ndr/LATS
subfamily of AGC (protein kinase A/PKG/PKC) kinases. It is a tumor suppressor gene
originally isolated from Drosophila and recently isolated from mice and humans. Drosophila
or mice mutant for LATS develop tumors in various tissues. Recent studies in Drosophila
demonstrate that LATS is a central player of an emerging tumor suppressor pathway called
the Hippo-LATS/Warts pathway that suppresses tumor growth by regulating cell proliferation …