Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc
A Schneider, K Peukert, M Eilers, F Hänel - C-Myc in B-Cell Neoplasia …, 1997 - Springer
A Schneider, K Peukert, M Eilers, F Hänel
C-Myc in B-Cell Neoplasia: 14th Workshop on Mechanisms in B-Cell Neoplasia, 1997•SpringerThe Myc protein activates transcription as part of a complex with its partner protein, Max. Myc-
transformed cells are also characterised by the loss of expression of a number of genes and
this repressive effect of Myc on gene expression may not be mediated by the Myc/Max
complex. We recently isolated by two-hybrid cloning a novel zinc-finger protein that
associates with the carboxy-terminus of Myc. We have termed this protein Miz-1 (M yc-
mteracting z inc finger protein). Some of the properties of Miz-1 suggest that it may be …
transformed cells are also characterised by the loss of expression of a number of genes and
this repressive effect of Myc on gene expression may not be mediated by the Myc/Max
complex. We recently isolated by two-hybrid cloning a novel zinc-finger protein that
associates with the carboxy-terminus of Myc. We have termed this protein Miz-1 (M yc-
mteracting z inc finger protein). Some of the properties of Miz-1 suggest that it may be …
Summary
The Myc protein activates transcription as part of a complex with its partner protein, Max. Myc-transformed cells are also characterised by the loss of expression of a number of genes and this repressive effect of Myc on gene expression may not be mediated by the Myc/Max complex. We recently isolated by two-hybrid cloning a novel zinc-finger protein that associates with the carboxy-terminus of Myc. We have termed this protein Miz-1 (Myc-mteracting zinc finger protein). Some of the properties of Miz-1 suggest that it may be involved in gene repression by Myc in vivo.
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