[HTML][HTML] Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
A Bahn, Y Hagos, S Reuter, D Balen, H Brzica… - Journal of Biological …, 2008 - ASBMB
The orphan transporter hORCTL3 (human organic cation transporter like 3; SLC22A13) is
highly expressed in kidneys and to a weaker extent in brain, heart, and intestine. hORCTL3-
expressing Xenopus laevis oocytes showed uptake of [3 H] nicotinate,[3 H] p-
aminohippurate, and [14 C] urate. Hence, hORCTL3 is an organic anion transporter, and we
renamed it hOAT10.[3 H] Nicotinate transport by hOAT10 into X. laevis oocytes and into
Caco-2 cells was saturable with Michaelis constants (K m) of 22 and 44 μm, respectively …
highly expressed in kidneys and to a weaker extent in brain, heart, and intestine. hORCTL3-
expressing Xenopus laevis oocytes showed uptake of [3 H] nicotinate,[3 H] p-
aminohippurate, and [14 C] urate. Hence, hORCTL3 is an organic anion transporter, and we
renamed it hOAT10.[3 H] Nicotinate transport by hOAT10 into X. laevis oocytes and into
Caco-2 cells was saturable with Michaelis constants (K m) of 22 and 44 μm, respectively …