Erythro-myeloid progenitors:“definitive” hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells
JM Frame, KE McGrath, J Palis - Blood Cells, Molecules, and Diseases, 2013 - Elsevier
Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the
developing conceptus prior to the formation of a permanent blood system. In this review, we
summarize the current knowledge regarding the emergence, fate, and potential of this
hematopoietic stem cell (HSC)-independent wave of hematopoietic progenitors, focusing on
the murine embryo as a model system. A better understanding of the temporal and spatial
control of hematopoietic emergence in the embryo will ultimately improve our ability to …
developing conceptus prior to the formation of a permanent blood system. In this review, we
summarize the current knowledge regarding the emergence, fate, and potential of this
hematopoietic stem cell (HSC)-independent wave of hematopoietic progenitors, focusing on
the murine embryo as a model system. A better understanding of the temporal and spatial
control of hematopoietic emergence in the embryo will ultimately improve our ability to …