von Hippel-Lindau disease
The Lancet, 2003•thelancet.com
Summary von Hippel-Lindau disease is a heritable multisystem cancer syndrome that is
associated with a germline mutation of the VHL tumour suppressor gene on the short arm of
chromosome 3. This disorder is not rare (about one in 36 000 livebirths) and is inherited as a
highly penetrant autosomal dominant trait (ie, with a high individual risk of disease). Affected
individuals are at risk of developing various benign and malignant tumours of the central
nervous system, kidneys, adrenal glands, pancreas, and reproductive adnexal organs …
associated with a germline mutation of the VHL tumour suppressor gene on the short arm of
chromosome 3. This disorder is not rare (about one in 36 000 livebirths) and is inherited as a
highly penetrant autosomal dominant trait (ie, with a high individual risk of disease). Affected
individuals are at risk of developing various benign and malignant tumours of the central
nervous system, kidneys, adrenal glands, pancreas, and reproductive adnexal organs …
Summary
von Hippel-Lindau disease is a heritable multisystem cancer syndrome that is associated with a germline mutation of the VHL tumour suppressor gene on the short arm of chromosome 3. This disorder is not rare (about one in 36 000 livebirths) and is inherited as a highly penetrant autosomal dominant trait (ie, with a high individual risk of disease). Affected individuals are at risk of developing various benign and malignant tumours of the central nervous system, kidneys, adrenal glands, pancreas, and reproductive adnexal organs. Because of the complexities associated with management of the various types of tumours in this disease, treatment is multidisciplinary. We present an overview of the clinical aspects, management, and treatment options for von Hippel-Lindau disease.
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