[HTML][HTML] Glucose and endoplasmic reticulum calcium channels regulate HIF-1β via presenilin in pancreatic β-cells
V Dror, TB Kalynyak, Y Bychkivska, MHZ Frey… - Journal of Biological …, 2008 - ASBMB
Pancreatic β-cell death is a critical event in type 1 diabetes, type 2 diabetes, and clinical islet
transplantation. We have previously shown that prolonged block of ryanodine receptor
(RyR)-gated release from intracellular Ca 2+ stores activates calpain-10-dependent
apoptosis in β-cells. In the present study, we further characterized intracellular Ca 2+
channel expression and function in human islets and the MIN6 β-cell line. All three RyR
isoforms were identified in human islets and MIN6 cells, and these endoplasmic reticulum …
transplantation. We have previously shown that prolonged block of ryanodine receptor
(RyR)-gated release from intracellular Ca 2+ stores activates calpain-10-dependent
apoptosis in β-cells. In the present study, we further characterized intracellular Ca 2+
channel expression and function in human islets and the MIN6 β-cell line. All three RyR
isoforms were identified in human islets and MIN6 cells, and these endoplasmic reticulum …