[HTML][HTML] Identification and characterization of polycystin-2, thePKD2 gene product
Y Cai, Y Maeda, A Cedzich, VE Torres, G Wu… - Journal of Biological …, 1999 - ASBMB
PKD2, the second gene for the autosomal dominant polycystic kidney disease (ADPKD),
encodes a protein, polycystin-2, with predicted structural similarity to cation channel
subunits. However, the function of polycystin-2 remains unknown. We used polyclonal
antisera specific for the intracellular NH 2 and COOH termini to identify polycystin-2 as an∼
110-kDa integral membrane glycoprotein. Polycystin-2 from both native tissues and cells in
culture is sensitive to Endo H suggesting the continued presence of high-mannose …
encodes a protein, polycystin-2, with predicted structural similarity to cation channel
subunits. However, the function of polycystin-2 remains unknown. We used polyclonal
antisera specific for the intracellular NH 2 and COOH termini to identify polycystin-2 as an∼
110-kDa integral membrane glycoprotein. Polycystin-2 from both native tissues and cells in
culture is sensitive to Endo H suggesting the continued presence of high-mannose …