[HTML][HTML] Getting in and out from calnexin/calreticulin cycles
JJ Caramelo, AJ Parodi - Journal of Biological Chemistry, 2008 - ASBMB
The N-glycan-dependent quality control mechanism of glycoprotein folding was proposed
initially by Helenius and coworkers several years ago; with a few minor modifications, it is
still valid today (Fig. 1)(1–3). 2 Glycan processing starts immediately after its transfer from a
dolichol-PP derivative to Asn residues in nascent polypeptide chains entering the lumen of
the ER. 3 Removal of the outermost and following glucoses by the successive action of GI
and GII exposes the Glc1Man9GlcNAc2 epitope (Fig. 2). This structure is then recognized by …
initially by Helenius and coworkers several years ago; with a few minor modifications, it is
still valid today (Fig. 1)(1–3). 2 Glycan processing starts immediately after its transfer from a
dolichol-PP derivative to Asn residues in nascent polypeptide chains entering the lumen of
the ER. 3 Removal of the outermost and following glucoses by the successive action of GI
and GII exposes the Glc1Man9GlcNAc2 epitope (Fig. 2). This structure is then recognized by …