[HTML][HTML] Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein
Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, protects
against oxidative stress, and shows potent anti-inflammatory effects. Oxidized
phospholipids, which are generated during inflammation and apoptosis, modulate the
inflammatory response by inducing the expression of several genes including HO-1. Here
we investigated the signaling pathways and transcriptional events involved in the induction
of HO-1 gene expression by oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3 …
against oxidative stress, and shows potent anti-inflammatory effects. Oxidized
phospholipids, which are generated during inflammation and apoptosis, modulate the
inflammatory response by inducing the expression of several genes including HO-1. Here
we investigated the signaling pathways and transcriptional events involved in the induction
of HO-1 gene expression by oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3 …