Glomerulosclerosis in a heterogeneous pattern, ie, focal and segmental glomerulosclerosis
(FSGS), is a common endpoint in a variety of settings, including idiopathic FSGS, and
scarring secondary to other renal or systemic diseases. These different causes contribute to
the diverse clinical outcomes of histological focal sclerosis, and the varying histologic
manifestations of sclerosis. Numerous models have been established in the rat that aim to
mirror the various elements of human glomerulosclerosis. With the availability of knockout …