Expression of cyr61, a growth factor-inducible immediate-early gene
TP O'brien, GP Yang, L Sanders… - Molecular and cellular …, 1990 - Am Soc Microbiol
A set of immediate-early genes that are rapidly activated by serum or purified platelet-
derived growth factor in mouse 3T3 fibroblasts has been previously identified. Among these
genes, several are related to known or putative transcription factors and growth factors,
supporting the notion that some of these genes encode regulatory molecules important to
cell growth. We show here that a member of this set of genes, cyr61 (originally identified by
its cDNA 3CH61), encodes a 379-amino-acid polypeptide rich in cysteine residues. cyr61 …
derived growth factor in mouse 3T3 fibroblasts has been previously identified. Among these
genes, several are related to known or putative transcription factors and growth factors,
supporting the notion that some of these genes encode regulatory molecules important to
cell growth. We show here that a member of this set of genes, cyr61 (originally identified by
its cDNA 3CH61), encodes a 379-amino-acid polypeptide rich in cysteine residues. cyr61 …
cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.
CH Charles, AS Abler, LF Lau - Oncogene, 1992 - europepmc.org
We report the cDNA sequence of 3CH134, an immediate early gene whose transcription is
rapidly and transiently stimulated by serum growth factors. 3CH134 encodes a 367 amino
acid protein that does not share significant sequence similarity with any known protein.
3CH134 is inducible through multiple signal transduction pathways, and in the adult mouse
is expressed predominantly in the lung. Using affinity-purified antibodies, we have identified
the 3CH134 protein in serum-stimulated Balb/c 3T3 cells and determined that it has a short …
rapidly and transiently stimulated by serum growth factors. 3CH134 encodes a 367 amino
acid protein that does not share significant sequence similarity with any known protein.
3CH134 is inducible through multiple signal transduction pathways, and in the adult mouse
is expressed predominantly in the lung. Using affinity-purified antibodies, we have identified
the 3CH134 protein in serum-stimulated Balb/c 3T3 cells and determined that it has a short …
Expression of the growth factor-inducible immediate early gene cyr61 correlates with chondrogenesis during mouse embryonic development
TP O'Brien, LF Lau - Cell growth and differentiation, 1992 - AACR
Abstract cyr61 is a growth factor-inducible immediate early gene initially identified in serum-
stimulated mouse fibroblasts. It encodes a member of an emerging family of cysteine-rich
secreted proteins that includes a connective tissue growth factor. We show here that cyr61 is
expressed in the developing mouse embryo and extraembryonic tissues. In the placenta,
cyr61 is expressed in regions of trophoblastic origin, including the ectoplacental cone and
the trophoblastic giant cells. In the midgestation embryo, cyr61 is expressed in the smooth …
stimulated mouse fibroblasts. It encodes a member of an emerging family of cysteine-rich
secreted proteins that includes a connective tissue growth factor. We show here that cyr61 is
expressed in the developing mouse embryo and extraembryonic tissues. In the placenta,
cyr61 is expressed in regions of trophoblastic origin, including the ectoplacental cone and
the trophoblastic giant cells. In the midgestation embryo, cyr61 is expressed in the smooth …