Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice
R Fiorotto, A Raizner, CM Morell, B Torsello… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Repair from biliary damages requires the biliary specification of
hepatic progenitor cells and the remodeling of ductular reactive structures into branching
biliary tubules. We hypothesized that the morphogenetic role of Notch signaling is
maintained during the repair process and have addressed this hypothesis using
pharmacologic and genetic models of defective Notch signaling. METHODS: Treatment with
DDC (3, 5-diethoxycarbonyl-1, 4-dihydrocollidine) or ANIT (alpha-naphthyl-isothiocyanate) …
hepatic progenitor cells and the remodeling of ductular reactive structures into branching
biliary tubules. We hypothesized that the morphogenetic role of Notch signaling is
maintained during the repair process and have addressed this hypothesis using
pharmacologic and genetic models of defective Notch signaling. METHODS: Treatment with
DDC (3, 5-diethoxycarbonyl-1, 4-dihydrocollidine) or ANIT (alpha-naphthyl-isothiocyanate) …