Livers are comprised of maturational lineages of cells beginning extrahepatically in the
hepato-pancreatic common duct near the duodenum and intrahepatically in zone 1 by the
portal triads. The extrahepatic stem cell niches are the peribiliary glands deep within the
walls of the bile ducts; those intrahepatically are the canals of Hering in postnatal livers and
that derive from ductal plates in fetal livers. Intrahepatically, there are at least eight
maturational lineage stages from the stem cells in zone 1 (periportal), through the midacinar …