GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord
CD Mills, AJ Allchorne, RS Griffin, CJ Woolf… - Molecular and Cellular …, 2007 - Elsevier
Axonal regeneration within the CNS fails due to the growth inhibitory environment and the
limited intrinsic growth capacity of injured neurons. Injury to DRG peripheral axons induces
expression of growth associated genes including members of the glial-derived neurotrophic
factor (GDNF) signaling pathway and “preconditions” the injured cells into an active growth
state, enhancing growth of their centrally projecting axons. Here, we show that
preconditioning DRG neurons prior to culturing increased neurite outgrowth, which was …
limited intrinsic growth capacity of injured neurons. Injury to DRG peripheral axons induces
expression of growth associated genes including members of the glial-derived neurotrophic
factor (GDNF) signaling pathway and “preconditions” the injured cells into an active growth
state, enhancing growth of their centrally projecting axons. Here, we show that
preconditioning DRG neurons prior to culturing increased neurite outgrowth, which was …