[HTML][HTML] Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

AK Lutz, N Exner, ME Fett, JS Schlehe, K Kloos… - Journal of Biological …, 2009 - ASBMB
Loss-of-function mutations in the parkin gene (PARK2) and PINK1 gene (PARK6) are
associated with autosomal recessive parkinsonism. PINK1 deficiency was recently linked to
mitochondrial pathology in human cells and Drosophila melanogaster, which can be
rescued by parkin, suggesting that both genes play a role in maintaining mitochondrial
integrity. Here we demonstrate that an acute down-regulation of parkin in human SH-SY5Y
cells severely affects mitochondrial morphology and function, a phenotype comparable with …