Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1, 4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with …
R Delle Chiaie, P Pancheri, P Scapicchio - The American journal of clinical …, 2002 - Elsevier
ABSTRACT Background: S-Adenosyl-l-methionine (SAMe), a natural compound, is the most
important methyl donor in the central nervous system. In several clinical trials, SAMe showed
antidepressant activity. Objective: Two multicenter studies were conducted in patients with a
diagnosis of major depressive episode [baseline score on the 21-item Hamilton Depression
Rating Scale (HAM-D)≥ 18] to confirm the efficacy and safety of SAMe in the treatment of
major depression. In the first study (MC3), 1600 mg SAMe/d was given orally; whereas, in …
important methyl donor in the central nervous system. In several clinical trials, SAMe showed
antidepressant activity. Objective: Two multicenter studies were conducted in patients with a
diagnosis of major depressive episode [baseline score on the 21-item Hamilton Depression
Rating Scale (HAM-D)≥ 18] to confirm the efficacy and safety of SAMe in the treatment of
major depression. In the first study (MC3), 1600 mg SAMe/d was given orally; whereas, in …