DNA methylation and gene function
A Razin, AD Riggs - Science, 1980 - science.org
A Razin, AD Riggs
Science, 1980•science.orgIn most higher organisms, DNA is modified after synthesis by the enzymatic conversion of
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by
DNA methylation has been recognized as a logically attractive possibility, but experimental
support has proved elusive. However, there is now reason to believe, from recent studies,
that DNA methylation is a key element in the hierarchy of control mechanisms that govern
vertebrate gene function and differentiation.
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by
DNA methylation has been recognized as a logically attractive possibility, but experimental
support has proved elusive. However, there is now reason to believe, from recent studies,
that DNA methylation is a key element in the hierarchy of control mechanisms that govern
vertebrate gene function and differentiation.
In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive. However, there is now reason to believe, from recent studies, that DNA methylation is a key element in the hierarchy of control mechanisms that govern vertebrate gene function and differentiation.
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