Gamma interferon release assay for monitoring of treatment response for active tuberculosis: an explosion in the spaghetti factory

CM Denkinger, M Pai, M Patel… - Journal of clinical …, 2013 - Am Soc Microbiol
CM Denkinger, M Pai, M Patel, D Menzies
Journal of clinical microbiology, 2013Am Soc Microbiol
Few studies have correlated the results of interferon (gamma interferon) release assays
(IGRAs) with known markers of tuberculosis (TB) treatment response. We report the results
of serial QuantiFERON-TB gold in-tube assay (QFT) testing on 149 patients with active
tuberculosis and correlate the results with smear and culture conversion. We show that QFT
results do not offer much value for treatment monitoring of TB disease.
Abstract
Few studies have correlated the results of interferon (gamma interferon) release assays (IGRAs) with known markers of tuberculosis (TB) treatment response. We report the results of serial QuantiFERON-TB gold in-tube assay (QFT) testing on 149 patients with active tuberculosis and correlate the results with smear and culture conversion. We show that QFT results do not offer much value for treatment monitoring of TB disease.
American Society for Microbiology