Impaired Degranulation and Proliferative Capacity of Mycobacterium tuberculosis–Specific CD8+ T Cells in HIV-Infected Individuals With Latent Tuberculosis

AS Kalokhe, T Adekambi, CC Ibegbu… - The Journal of …, 2015 - academic.oup.com
AS Kalokhe, T Adekambi, CC Ibegbu, SM Ray, CL Day, J Rengarajan
The Journal of infectious diseases, 2015academic.oup.com
Human immunodeficiency virus (HIV)-infected individuals with latent Mycobacterium
tuberculosis infection have substantially higher rates of progression to active tuberculosis
than HIV-uninfected individuals with latent tuberculosis. To explore HIV-induced deficits in
M. tuberculosis–specific CD8+ T-cell functions, we compared interferon γ production,
degranulation, and proliferation of CD8+ T cells in response to M. tuberculosis peptides
(ESAT-6/CFP-10) between HIV-infected (median CD4+ T-cell count, 522 cells/µL; …
Human immunodeficiency virus (HIV)-infected individuals with latent Mycobacterium tuberculosis infection have substantially higher rates of progression to active tuberculosis than HIV-uninfected individuals with latent tuberculosis. To explore HIV-induced deficits in M. tuberculosis–specific CD8+ T-cell functions, we compared interferon γ production, degranulation, and proliferation of CD8+ T cells in response to M. tuberculosis peptides (ESAT-6/CFP-10) between HIV-infected (median CD4+ T-cell count, 522 cells/µL; interquartile range, 318–585 cells/µL) and HIV-uninfected individuals with latent tuberculosis from South Africa. We found that M. tuberculosis–specific degranulation and proliferative capacities were impaired in the HIV-infected group. Thus, our results suggest that HIV coinfection compromises CD8+ T-cell functions in latent tuberculosis.
Oxford University Press