Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration
N Gupta, KE Brown, AH Milam - Experimental eye research, 2003 - Elsevier
Many gaps exist in our knowledge of human retinal microglia in health and disease. We
address the hypothesis that primary death of rod photoreceptors leads to activation of
resident microglia in human retinas with retinitis pigmentosa (RP), late-onset retinal
degeneration (L-ORD), or age-related macular degeneration (AMD). Regions of ongoing
photoreceptor cell death were studied by immunocytochemistry with microglia-and other
retinal cell-specific markers. In normal human retinas, quiescent microglia were small …
address the hypothesis that primary death of rod photoreceptors leads to activation of
resident microglia in human retinas with retinitis pigmentosa (RP), late-onset retinal
degeneration (L-ORD), or age-related macular degeneration (AMD). Regions of ongoing
photoreceptor cell death were studied by immunocytochemistry with microglia-and other
retinal cell-specific markers. In normal human retinas, quiescent microglia were small …