Combinatorial therapy stimulates long-distance regeneration, target reinnervation, and partial recovery of vision after optic nerve injury in mice
The optic nerve has been widely studied for insights into mechanisms that suppress or
promote axon regeneration after central nervous system injury. Following optic nerve
damage in adult mammals, retinal ganglion cells (RGCs) normally fail to regenerate their
axons, resulting in blindness in patients who suffer from neurodegenerative diseases such
as glaucoma or who have sustained traumatic injury to the optic nerve. Over the past several
decades, many groups have investigated the basis of regenerative failure in the hope of …
promote axon regeneration after central nervous system injury. Following optic nerve
damage in adult mammals, retinal ganglion cells (RGCs) normally fail to regenerate their
axons, resulting in blindness in patients who suffer from neurodegenerative diseases such
as glaucoma or who have sustained traumatic injury to the optic nerve. Over the past several
decades, many groups have investigated the basis of regenerative failure in the hope of …