[HTML][HTML] Regulation of Casein Kinase I ε and Casein Kinase I δ by Anin Vivo Futile Phosphorylation Cycle
A Rivers, KF Gietzen, E Vielhaber… - Journal of Biological …, 1998 - ASBMB
Casein kinase I δ (CKIδ) and casein kinase I ε (CKIε) have been implicated in the response
to DNA damage, but the understanding of how these kinases are regulated remains
incomplete. In vitro, these kinases rapidly autophosphorylate, predominantly on their
carboxyl-terminal extensions, and this autophosphorylation markedly inhibits kinase activity
(Cegielska, A., Gietzen, KF, Rivers, A., and Virshup, DM (1998) J. Biol. Chem. 273, 1357–
1364). However, we now report that while these kinases are able to autophosphorylatein …
to DNA damage, but the understanding of how these kinases are regulated remains
incomplete. In vitro, these kinases rapidly autophosphorylate, predominantly on their
carboxyl-terminal extensions, and this autophosphorylation markedly inhibits kinase activity
(Cegielska, A., Gietzen, KF, Rivers, A., and Virshup, DM (1998) J. Biol. Chem. 273, 1357–
1364). However, we now report that while these kinases are able to autophosphorylatein …