Post-translational modifications regulate the ticking of the circadian clock
M Gallego, DM Virshup - Nature reviews Molecular cell biology, 2007 - nature.com
Nature reviews Molecular cell biology, 2007•nature.com
Getting a good night's sleep is on everyone's to-do list. So is, no doubt, staying awake during
late afternoon seminars. Our internal clocks control these and many more workings of the
body, and disruptions of the circadian clocks predispose individuals to depression, obesity
and cancer. Mutations in kinases and phosphatases in hamsters, flies, fungi and humans
highlight how our timepieces are regulated and provide clues as to how we might be able to
manipulate them.
late afternoon seminars. Our internal clocks control these and many more workings of the
body, and disruptions of the circadian clocks predispose individuals to depression, obesity
and cancer. Mutations in kinases and phosphatases in hamsters, flies, fungi and humans
highlight how our timepieces are regulated and provide clues as to how we might be able to
manipulate them.
Abstract
Getting a good night's sleep is on everyone's to-do list. So is, no doubt, staying awake during late afternoon seminars. Our internal clocks control these and many more workings of the body, and disruptions of the circadian clocks predispose individuals to depression, obesity and cancer. Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how our timepieces are regulated and provide clues as to how we might be able to manipulate them.
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