Mitochondria, the site of oxidative energy metabolism in eukariotic cells, are a highly
organised structure endowed with different enzymes and reactions localized in discrete
membranes and aqueous compartments. Mitochondrial function is regulated in complex
ways by several agonists and environmental conditions, through activation of specific
transcription factors and signalling pathways. A key player in this scenario is nitric oxide
(NO). Its binding to cytochrome c oxidase in the mitochondrial respiratory chain, which is …