[HTML][HTML] Critical role for STAT3 in murine pituitary adrenocorticotropin hormone leukemia inhibitory factor signaling
C Bousquet, S Melmed - Journal of Biological Chemistry, 1999 - ASBMB
Leukemia inhibitory factor (LIF) is a pleiotropic neuroimmune cytokine that promotes
corticotroph cell differentiation and induces proopiomelanocortin (POMC) mRNA expression
and adrenocorticotropin hormone (ACTH) secretion. However, molecular mechanisms for
this induction remain elusive. We therefore developed ACTH-secreting AtT20 transformants
for wild-type or mutated STAT3, a cytokine signaling molecule, to address whether STAT3 is
a determinant of LIF-mediated ACTH regulation. We show that these mutants act in a …
corticotroph cell differentiation and induces proopiomelanocortin (POMC) mRNA expression
and adrenocorticotropin hormone (ACTH) secretion. However, molecular mechanisms for
this induction remain elusive. We therefore developed ACTH-secreting AtT20 transformants
for wild-type or mutated STAT3, a cytokine signaling molecule, to address whether STAT3 is
a determinant of LIF-mediated ACTH regulation. We show that these mutants act in a …