Transcription factors are major determinants of cell-specific gene expression in all cell types.
Studies in rodent liver have shown that alterations in transcription factor expression
determine lineage specification during fetal liver development and signify transdifferentiation
of cells of the biliary compartment into 'oval'cells and eventually hepatocytes in adult liver.
We examined the cellular localization of hepatocyte-or BEC-associated transcription factors
in human fetal and adult liver and in diseases in which transdifferentiation between …