Listeriosis in human pregnancy: a systematic review

RF Lamont, J Sobel, S Mazaki-Tovi, JP Kusanovic… - 2011 - degruyter.com
RF Lamont, J Sobel, S Mazaki-Tovi, JP Kusanovic, E Vaisbuch, SK Kim, N Uldbjerg
2011degruyter.com
Listeria is commonly found in processed and prepared foods and listeriosis is associated
with high morbidity and mortality. Preventative measures are well prescribed and monitoring
and voluntary recall of contaminated products has resulted in a 44% reduction in the
prevalence of perinatal listeriosis in the USA. Pregnant women are at high risk for listeriosis,
but symptoms are non-specific and diagnosis is difficult. The intracellular life-cycle of Listeria
protects the bacterium from host innate and adaptive immune responses. Antibiotic …
Abstract
Listeria is commonly found in processed and prepared foods and listeriosis is associated with high morbidity and mortality. Preventative measures are well prescribed and monitoring and voluntary recall of contaminated products has resulted in a 44% reduction in the prevalence of perinatal listeriosis in the USA. Pregnant women are at high risk for listeriosis, but symptoms are non-specific and diagnosis is difficult. The intracellular life-cycle of Listeria protects the bacterium from host innate and adaptive immune responses. Antibiotic treatment requires agents able to penetrate, distribute, and remain stable within host cells. Prolonged use of high-dose ampicillin can significantly improve neonatal outcome.
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