[HTML][HTML] Perinatal pandemic (H1N1) 2009 infection, Thailand

W Dulyachai, J Makkoch, P Rianthavorn… - Emerging Infectious …, 2010 - ncbi.nlm.nih.gov
W Dulyachai, J Makkoch, P Rianthavorn, M Changpinyo, S Prayangprecha, S Payungporn
Emerging Infectious Diseases, 2010ncbi.nlm.nih.gov
To the Editor: Infection with influenza A pandemic (H1N1) 2009 has been reported
worldwide following initial identification of the virus in April 2009 (1). The groups at highest
risk for infection or influenza-related complications include pregnant women and children
(2). We report a case of pandemic (H1N1) 2009 infection in a newborn whose mother
became ill with pandemic (H1N1) 2009 during the perinatal period. A newborn girl showed
signs of respiratory distress. The relevant perinatal history was maternal illness with …
To the Editor: Infection with influenza A pandemic (H1N1) 2009 has been reported worldwide following initial identification of the virus in April 2009 (1). The groups at highest risk for infection or influenza-related complications include pregnant women and children (2). We report a case of pandemic (H1N1) 2009 infection in a newborn whose mother became ill with pandemic (H1N1) 2009 during the perinatal period. A newborn girl showed signs of respiratory distress. The relevant perinatal history was maternal illness with pandemic (H1N1) 2009 7 days before delivery. The infant, who had a birth weight of 1,560 grams, was delivered by emergency cesarean section after the mother experienced cardiopulmonary failure at the gestational age of 31 weeks. Apgar scores were 9 and 9 at 1 and 5 minutes, respectively. Physical examination at birth showed a premature infant girl with mild subcostal retraction. Oxygen saturation at room air was 91%–99%. Other results of the physical examination were unremarkable.
Initial management included routine care for premature infants. On the basis of the perinatal history, a throat swab specimen was collected for pandemic (H1N1) 2009 testing by PCR and oseltamivir, 6 mg, was administered every 12 hours (4 mg/kg/day). The specimen obtained from the throat swab was positive for pandemic (H1N1) 2009 by real-time PCR. The infant required oxygen supplementation. At day 2 of life, acute renal failure with an elevated plasma creatinine level of 1.1 mg/dL developed in the infant. Chest radiograph showed minimal pulmonary infiltrations. She was started on cefotaxime for suspected sepsis. Oseltamivir dosage was adjusted based on the glomerular fil-
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