Typhoid fever is a systemic, persistent infection caused by host-specific strains of
Salmonella. Although the use of antibiotics has reduced the complications associated with
primary infection, recurrent infection remains an important cause of ongoing human
morbidity and mortality. Herein, we investigated the impacts of antibiotic eradication of
primary infection on protection against secondary recurrent infection. Using a murine model
of persistent Salmonella infection, we demonstrate protection against recurrent infection is …