Nonhuman Primate Model for Listeria monocytogenes-Induced Stillbirths
MA Smith, K Takeuchi, RE Brackett… - Infection and …, 2003 - Am Soc Microbiol
MA Smith, K Takeuchi, RE Brackett, HM McClure, RB Raybourne, KM Williams, US Babu…
Infection and Immunity, 2003•Am Soc MicrobiolListeria monocytogenes, isolated from outbreaks in either human or nonhuman primate
populations, was administered orally at doses ranging from 106 to 1010 CFU. Four of 10
treated animals delivered stillborn infants. L. monocytogenes was isolated from fetal tissue,
and the pathology was consistent with L. monocytogenes infection as the cause of
pregnancy loss. For all pregnancies resulting in stillbirths, L. monocytogenes was isolated
from maternal feces, indicating that L. monocytogenes had survived and had probably …
populations, was administered orally at doses ranging from 106 to 1010 CFU. Four of 10
treated animals delivered stillborn infants. L. monocytogenes was isolated from fetal tissue,
and the pathology was consistent with L. monocytogenes infection as the cause of
pregnancy loss. For all pregnancies resulting in stillbirths, L. monocytogenes was isolated
from maternal feces, indicating that L. monocytogenes had survived and had probably …
Abstract
Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging from 106 to 1010 CFU. Four of 10 treated animals delivered stillborn infants. L. monocytogenes was isolated from fetal tissue, and the pathology was consistent with L. monocytogenes infection as the cause of pregnancy loss. For all pregnancies resulting in stillbirths, L. monocytogenes was isolated from maternal feces, indicating that L. monocytogenes had survived and had probably colonized the gastrointestinal tract. Antibodies and antigen-specific lymphocyte proliferation against Listeria increased in animals that had stillbirths.
American Society for Microbiology