[HTML][HTML] Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem …
EZH2, a catalytic subunit of Polycomb-repressive complex 2 (PRC2), is a histone lysine
methyltransferase that methylates lysine 27 of histone H3, resulting in gene silencing. It has
been shown that EZH2 plays a pivotal role in fostering self-renewal and inhibiting the
differentiation of embryonic stem cells. Mesenchymal stem cells (MSCs) can be induced to
differentiate into adipogenic and osteogenic lineages, which are mutually exclusive.
However, it is not clear whether the molecular events of EZH2-mediated epigenetic silencing …
methyltransferase that methylates lysine 27 of histone H3, resulting in gene silencing. It has
been shown that EZH2 plays a pivotal role in fostering self-renewal and inhibiting the
differentiation of embryonic stem cells. Mesenchymal stem cells (MSCs) can be induced to
differentiate into adipogenic and osteogenic lineages, which are mutually exclusive.
However, it is not clear whether the molecular events of EZH2-mediated epigenetic silencing …