The TIM-1: TIM-4 pathway enhances renal ischemia-reperfusion injury
S Rong, JK Park, T Kirsch, H Yagita… - Journal of the …, 2011 - journals.lww.com
CD4+ T cells contribute to the pathogenesis of ischemia-reperfusion injury, which is the
primary cause of delayed graft failure after kidney transplantation. The TIM-1: TIM-4 pathway
participates in the activation/differentiation of CD4+ T cells, suggesting that it may modulate
ischemia-reperfusion injury. Here, we studied the role of TIM-1 in a murine
uninephrectomized renal ischemia-reperfusion injury model. Blocking the TIM-1: TIM-4
pathway with an antagonistic monoclonal antibody protected renal function and diminished …
primary cause of delayed graft failure after kidney transplantation. The TIM-1: TIM-4 pathway
participates in the activation/differentiation of CD4+ T cells, suggesting that it may modulate
ischemia-reperfusion injury. Here, we studied the role of TIM-1 in a murine
uninephrectomized renal ischemia-reperfusion injury model. Blocking the TIM-1: TIM-4
pathway with an antagonistic monoclonal antibody protected renal function and diminished …