[HTML][HTML] Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density
JR Stephenson, KJ Paavola, SA Schaefer… - Journal of Biological …, 2013 - ASBMB
Brain-specific angiogenesis inhibitor-1 (BAI1) is an adhesion G protein-coupled receptor
that has been studied primarily for its anti-angiogenic and anti-tumorigenic properties. We
found that overexpression of BAI1 results in activation of the Rho pathway via a Gα 12/13-
dependent mechanism, with truncation of the BAI1 N terminus resulting in a dramatic
enhancement in receptor signaling. This constitutive activity of the truncated BAI1 mutant
also resulted in enhanced downstream phosphorylation of ERK as well as increased …
that has been studied primarily for its anti-angiogenic and anti-tumorigenic properties. We
found that overexpression of BAI1 results in activation of the Rho pathway via a Gα 12/13-
dependent mechanism, with truncation of the BAI1 N terminus resulting in a dramatic
enhancement in receptor signaling. This constitutive activity of the truncated BAI1 mutant
also resulted in enhanced downstream phosphorylation of ERK as well as increased …