[HTML][HTML] The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
C Sawallisch, K Berhörster, A Disanza… - Journal of biological …, 2009 - ASBMB
IRSp53 is an essential intermediate between the activation of Rac and Cdc42 GTPases and
the formation of cellular protrusions; it affects cell shape by coupling membrane-deforming
activity with the actin cytoskeleton. IRSp53 is highly expressed in neurons where it is also an
abundant component of the postsynaptic density (PSD). Here we analyze the physiological
function of this protein in the mouse brain by generating IRSp53-deficient mice. Neurons in
the hippocampus of young and adult knock-out (KO) mice do not exhibit morphological …
the formation of cellular protrusions; it affects cell shape by coupling membrane-deforming
activity with the actin cytoskeleton. IRSp53 is highly expressed in neurons where it is also an
abundant component of the postsynaptic density (PSD). Here we analyze the physiological
function of this protein in the mouse brain by generating IRSp53-deficient mice. Neurons in
the hippocampus of young and adult knock-out (KO) mice do not exhibit morphological …