A synaptic model of memory: long-term potentiation in the hippocampus

TVP Bliss, GL Collingridge - Nature, 1993 - nature.com
TVP Bliss, GL Collingridge
Nature, 1993nature.com
Long-term potentiation of synaptic transmission in the hippocampus is the primary
experimental model for investigating the synaptic basis of learning and memory in
vertebrates. The best understood form of long-term potentiation is induced by the activation
of the N-methyl-d-aspartate receptor complex. This subtype of glutamate receptor endows
long-term potentiation with Hebbian characteristics, and allows electrical events at the
postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to …
Abstract
Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength.
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