Temporal lobe impairment in W est syndrome: Event‐related potential evidence
K Werner, T Fosi, SG Boyd, T Baldeweg… - Annals of …, 2015 - Wiley Online Library
Annals of Neurology, 2015•Wiley Online Library
Objective This study investigates auditory processing in infants with West syndrome (WS)
using event‐related potentials (ERPs). Methods ERPs were measured in 25 infants with
mainly symptomatic WS (age range= 3–10 months) and 26 healthy term infants (age range=
3–9 months) using an auditory novelty oddball paradigm. The ERP recordings were made
during wakefulness and repeated in stage II sleep. Results The obligatory components
(P150, N250, P350) and novelty response components (P300, Nc) were recordable during …
using event‐related potentials (ERPs). Methods ERPs were measured in 25 infants with
mainly symptomatic WS (age range= 3–10 months) and 26 healthy term infants (age range=
3–9 months) using an auditory novelty oddball paradigm. The ERP recordings were made
during wakefulness and repeated in stage II sleep. Results The obligatory components
(P150, N250, P350) and novelty response components (P300, Nc) were recordable during …
Objective
This study investigates auditory processing in infants with West syndrome (WS) using event‐related potentials (ERPs).
Methods
ERPs were measured in 25 infants with mainly symptomatic WS (age range = 3–10 months) and 26 healthy term infants (age range = 3–9 months) using an auditory novelty oddball paradigm. The ERP recordings were made during wakefulness and repeated in stage II sleep.
Results
The obligatory components (P150, N250, P350) and novelty response components (P300, Nc) were recordable during both sleep and wakefulness in patients and controls. All ERP latencies decreased with age in controls but not in the WS group (age × group interaction, F = 22.3, p < 0.0001). These ERP latency alterations were not affected by pharmacological treatment for WS.
Interpretation
This study demonstrated a persistently altered ERP signature in patients with a recent history of infantile spasms. The prolongation of auditory obligatory and novelty ERPs in WS patients indicates a severe failure of temporal lobe maturation during infancy. It remains to be investigated whether this predicts long‐term cognitive impairments characteristic for this epileptic encephalopathy. ANN NEUROL 2015;77:47–57
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