[HTML][HTML] Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice

JG Wang, D Manly, D Kirchhofer, R Pawlinski… - Journal of Thrombosis …, 2009 - Elsevier
Background: Tissue factor (TF) is present in blood in various forms, including small
membrane vesicles called microparticles (MPs). Elevated levels of these MPs appear to play
a role in the pathogenesis of thrombosis in a variety of diseases, including sepsis. Objective:
Measure levels of MP TF activity and activation of coagulation in control and endotoxemic
mice. Materials and methods: MPs were prepared from plasma by centrifugation. The
procoagulant activity (PCA) of MPs was measured using a two‐stage chromogenic assay …