Filamins as integrators of cell mechanics and signalling
TP Stossel, J Condeelis, L Cooley, JH Hartwig… - … reviews Molecular cell …, 2001 - nature.com
TP Stossel, J Condeelis, L Cooley, JH Hartwig, A Noegel, M Schleicher, SS Shapiro
Nature reviews Molecular cell biology, 2001•nature.comFilamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs
and link them to cellular membranes. They integrate cellular architectural and signalling
functions and are essential for fetal development and cell locomotion. Here, we describe the
history, structure and function of this group of proteins.
and link them to cellular membranes. They integrate cellular architectural and signalling
functions and are essential for fetal development and cell locomotion. Here, we describe the
history, structure and function of this group of proteins.
Abstract
Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.
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