[HTML][HTML] Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
C Juliana, T Fernandes-Alnemri, J Wu, P Datta… - Journal of Biological …, 2010 - ASBMB
Activation of the inflammasome generates the pro-inflammatory cytokines interleukin-1β and-
18, which are important mediators of inflammation. Abnormal activation of the inflammasome
leads to many inflammatory diseases, including gout, silicosis, neurodegeneration, and
genetically inherited periodic fever syndromes. Therefore, identification of small molecule
inhibitors that target the inflammasome is an important step toward developing effective
therapeutics for the treatment of inflammation. Here, we show that the herbal NF-κB …
18, which are important mediators of inflammation. Abnormal activation of the inflammasome
leads to many inflammatory diseases, including gout, silicosis, neurodegeneration, and
genetically inherited periodic fever syndromes. Therefore, identification of small molecule
inhibitors that target the inflammasome is an important step toward developing effective
therapeutics for the treatment of inflammation. Here, we show that the herbal NF-κB …