[HTML][HTML] 3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264. 7 cells
A GuezGuez, V Prod'homme, X Mouska… - Journal of biological …, 2010 - ASBMB
The adapter protein 3BP2 (also known as SH3BP2 and Abl SH3-binding protein 2) has
been involved in leukocyte signaling and activation downstream immunoreceptors. Genetic
studies have further associated 3BP2 mutations to the human disease cherubism and to
inflammation and bone dysfunction in mouse. However, how wild type 3BP2 functions in
macrophage differentiation remains poorly understood. In this study, using small interfering
RNA-mediated silencing of 3BP2 in the RAW264. 7 monocytic cell line, we show that 3BP2 …
been involved in leukocyte signaling and activation downstream immunoreceptors. Genetic
studies have further associated 3BP2 mutations to the human disease cherubism and to
inflammation and bone dysfunction in mouse. However, how wild type 3BP2 functions in
macrophage differentiation remains poorly understood. In this study, using small interfering
RNA-mediated silencing of 3BP2 in the RAW264. 7 monocytic cell line, we show that 3BP2 …