Oral administration of the oxidant-scavenger N-acetyl-L-cysteine inhibits acute experimental autoimmune encephalomyelitis
D Lehmann, D Karussis, R Misrachi-Koll… - Journal of …, 1994 - Elsevier
The prevention of acute experimental autoimmune encephalomyelitis (EAE) by N-acetyl-l-
cysteine (NAC), a potent free radical scavenger, is described. Administrated ad libitum to
SJL/J mice at a dosage of 0.2–2 mg/ml in drinking water from the day of the
encephalitogenic injection, the agent significantly inhibited the induction of acute EAE. The
improvement in clinical condition was dose-dependent. A complete protective effect required
administration of the agent at an early stage. Examination of lymphocytes from NAC-treated …
cysteine (NAC), a potent free radical scavenger, is described. Administrated ad libitum to
SJL/J mice at a dosage of 0.2–2 mg/ml in drinking water from the day of the
encephalitogenic injection, the agent significantly inhibited the induction of acute EAE. The
improvement in clinical condition was dose-dependent. A complete protective effect required
administration of the agent at an early stage. Examination of lymphocytes from NAC-treated …