The S1P2 sphingosine 1-phosphate receptor is essential for auditory and vestibular function
AJ MacLennan, SJ Benner, A Andringa, AH Chaves… - Hearing research, 2006 - Elsevier
Sphingosine 1-phosphate (S1P) is an endogenous growth factor with potent effects on many
different cell types. Most of these effects are produced by activation of one or more of a
family of G-protein coupled receptors. The S1P2 receptor can mediate S1P-induced
proliferation, differentiation and survival in a wide variety of cells in culture. However,
identifying essential in vivo functions for S1P2 has been hampered by its ubiquitous
expression and the failure to detect any anatomical abnormalities in initial analyses of S1P2 …
different cell types. Most of these effects are produced by activation of one or more of a
family of G-protein coupled receptors. The S1P2 receptor can mediate S1P-induced
proliferation, differentiation and survival in a wide variety of cells in culture. However,
identifying essential in vivo functions for S1P2 has been hampered by its ubiquitous
expression and the failure to detect any anatomical abnormalities in initial analyses of S1P2 …