[HTML][HTML] Deafness and stria vascularis defects in S1P2 receptor-null mice

M Kono, IA Belyantseva, A Skoura, GI Frolenkov… - Journal of Biological …, 2007 - ASBMB
The S1P 2 receptor is a member of a family of G protein-coupled receptors that bind the
extracellular sphingolipid metabolite sphingosine 1-phosphate with high affinity. The
receptor is widely expressed and linked to multiple G protein signaling pathways, but its
physiological function has remained elusive. Here we have demonstrated that S1P 2
receptor expression is essential for proper functioning of the auditory and vestibular
systems. Auditory brainstem response analysis revealed that S1P 2 receptor-null mice were …