[HTML][HTML] Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning
K Mendelson, T Zygmunt, J Torres-Vázquez… - Journal of Biological …, 2013 - ASBMB
Sphingosine 1-phosphate (S1P) binds G-protein-coupled receptors (S1P 1–5) to regulate a
multitude of physiological effects, especially those in the vascular and immune systems. S1P
receptors in the vascular system have been characterized primarily in mammals. Here, we
report that the S1P receptors and metabolic enzymes are conserved in the genome of
zebrafish Danio rerio. Bioinformatic analysis identified seven S1P receptor-like sequences
in the zebrafish genome, including duplicated orthologs of receptors 3 and 5 …
multitude of physiological effects, especially those in the vascular and immune systems. S1P
receptors in the vascular system have been characterized primarily in mammals. Here, we
report that the S1P receptors and metabolic enzymes are conserved in the genome of
zebrafish Danio rerio. Bioinformatic analysis identified seven S1P receptor-like sequences
in the zebrafish genome, including duplicated orthologs of receptors 3 and 5 …