[HTML][HTML] HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects
KM Argraves, WS Argraves - Journal of lipid research, 2007 - ASBMB
The lysosphingolipid sphingosine 1-phosphate (S1P) is a component of HDL. Findings from
a growing number of studies indicate that S1P is a mediator of many of the cardiovascular
effects of HDL, including the ability to promote vasodilation, vasoconstriction, and
angiogenesis, protect against ischemia/reperfusion injury, and inhibit/reverse
atherosclerosis. These latter cardioprotective effects are being shown to involve the S1P-
mediated suppression of inflammatory processes, including reduction of the endothelial …
a growing number of studies indicate that S1P is a mediator of many of the cardiovascular
effects of HDL, including the ability to promote vasodilation, vasoconstriction, and
angiogenesis, protect against ischemia/reperfusion injury, and inhibit/reverse
atherosclerosis. These latter cardioprotective effects are being shown to involve the S1P-
mediated suppression of inflammatory processes, including reduction of the endothelial …